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Sulfate
Type ID: 1 (pKa ~2)
8% solids
These microspheres
are stabilized by sulfate charges. In some cases, hydroxyl and carboxyl groups
are also present in small amounts bound to the polymer chains. Depending upon the conditions of manufacture and
the particle size, the surface charge density of sulfate groups
ranges from about one charge group for every 200 Ų
of particle surface down to one group for every 2000 Ų
of surface. The pKa of the sulfate group is <2 and consequently
the particles are stable in acidic media. Suspensions of the
particles are stable up to almost 0.30 M univalent electrolyte
concentrations and therefore may be used in media of physiological
ionic strength. However they are hydrophobic particles and will
undergo aggregation in the presence of low concentrations of
divalent or trivalent cations unless stabilized by a hydrophilic coating. Sulfate latex is suitable for calibration of particle size analysis
equipment and are also appropriate for use in diagnostic test
systems which rely upon physical adsorption of antigens or antibodies.
See Protocol
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